Treatment for Iron Deficiency Anemia.


Iron deficiency anemia is a condition in which blood lack adequate healthy red blood cells. Red blood cells carry oxygen to the body's tissues. Take Sorbifer Durules for sustained release of Iron Therapy and win against Iron Deficiency Anemia.



For treatment of IRON DEFICIENCY ANEMIA, Sorbifer is 100mg elemental iron with 60mg of Vitamin C for better absorption of iron.

Ferrous Sulfate will help you meet higher requirements of iron during this child-bearing period at 1-2 tablets a day. Ferrous Sulfate will prepare your body for your precious one's delivery. For your body's replenishment, you can continue taking Ferrous Sulfate until postpartum period.

Product Information


Formulation

Each sustained-release tablet contains 310mg dried Ferrous sulfate (equivalent to 100mg elemental iron).

Pharmacokinetics

Iron is irregularly and incompletely absorbed from the gastrointestinal tract, the main sites of absorption being the duodenum and jejunum. Absorption is aided by the acid secretion of the stomach and by some dietery acids (such as ascorbic acid) and occurs more readiy when the iron is in the ferrous state or is part of the haem complex (haem-iron). Absorption is also increased in conditions of iron deficiency or in the fasting state but is decreased if the body stores are overloaded. Normally only about 5 to 15% of the iron ingested in food is absorbed.

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Properties

Durules provide continuous release of active substance. Studies using the double-isotope technique have shown that iron administered in the form of Ferrous Sulfate Durules is better utilized by the body than iron in ordinary tablets. This good absorption does not result in increased side effects. The occurrence of nausea and gastric pain is less with Ferrous Sulfate Durules than with conventional tablets.

Indication

For the prevention and treatment of iron deficiency.

Precautions

Iron compounds should not be given to patients receiving repeated blood transfusions or to patients with anaemias not produced by iron deficiency unless iron deficiency is also present. Oral iron therapy should not be used together. Care should be taken in patients with iron-storage or iron-absorption diseases such as haemochromatosis, haemoglobinopathies, or existing gastrointestinal diseases such as inflammatory bowel disease, intestinal structures and divertculae.

Liquid preparations containing iron salrs should be well diluted with water and swallowed through a straw to prevent discoloration of teeth.

Adverse Effects

The astringent action of oral iron preparations sometimes produces gastrointestinal irritation and abdominal pain with nausea and vomitting. These irritant side effects are usually related to the amount of elemental iron taken rather than the tpe of preparation. Other gastrointestinal effects may include either diarrhoea or constipation. Side effects can be reduced by giving it with or after food (rather than on an empty stomach) or by beginning therapy with a small dose and increasing gradually. Modified-release products are claimed to produce fewer side effects but this may only reflect the lower availability of iron from these preparations. Oral liquid preparations containing iron salts may blacken the teeth and should be drunk through a straw. The faeces of patients taking iron salts may be colored black.

Dosage and Administration

Adults: Ferrous Sulfate one tablet daily provides adequate therapy fo the majority of patients. When a more rapid hemoglobin response is required, an extra dose in the morning is of advantage. If necessary, the dosage may be further increased by 1 to 2 tablets daily.

As prophylaxis during pregnancy: During the 1st to 6th month of pregnancy, 1 tablet daily. During the final months, the dosage should be increased to one tablet morning and evening.

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Interactions

Iron salts are not well absorbed by mouth, and food may futher impair their absorption.
Compounds containing calcium and magnesium, including antacids and mineral supplements, and bicarbonates, carbonates, oxalates, or phosphates, may impair the absorption of iron by the formation of insoluble complexes. Similarly, the absorption of both iron salts and tetracyclines is diminised when taken together orally. If treatment with both drugs is required, a time interval of about 2 to 3 hours should be allowed between them. A suitable interval is also advised if an iron supplement is needed in patients given trientine. Zinc salts may decrease the absorption of iron. Iron is chelated by acetohydroxamic acid, reducing the absorption of both. Iron should not be given with dimercaprol as toxic complexes may form.

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